In animals, a Western style diet-high in saturated fat and added sugar-causes impairments in hippocampal-dependent learning and memory (HDLM) and perception of internal bodily state (interoception).In humans, while there is correlational support for a link between Western-style diet, HDLM, and interoception, there is as yet no causal data.Here, hea
Therapeutic potential of Fingolimod in triple negative breast cancer preclinical models
Surgery followed by a chemotherapy agent is the first-line treatment for breast cancer patients.Nevertheless, new targets are required for women with triple-negative breast cancer (TNBC) in order to improve the treatment of this aggressive cancer subtype.Multiple pro-inflammatory molecules including lipid-based substances such as sphingosine-1-phos
Impact of Deuteration and Temperature on Furan Ring Dynamics
Despite significant progress in conformational analysis of cyclic molecules, the number of computational studies is still limited while most of that available in the literature data have been obtained long time ago with outdated methods.In present research, we have studied temperature driven conformational changes of the furan ring at three differe
A phase I open-label study of the safety and efficacy of apatinib (rivoceranib) administered to patients with advanced malignancies to improve sensitivity to pembrolizumab in the second- or later-line setting (APPEASE)
Abstract Objective APPEASE is a phase I study to assess OIl the safety, dosing, and efficacy of rivoceranib (a selective, small-molecule inhibitor of VEGFR2) in combination with pembrolizumab.We aimed to treat patients with metastatic malignancies who have progressed through at least first-line therapy, with pembrolizumab 200 mg every 3 weeks, as w